Phloretin Suppresses Bone Morphogenetic Protein-2-Induced Osteoblastogenesis and Mineralization via Inhibition of Phosphatidylinositol 3-kinases/Akt Pathway

Phloretin Suppresses Bone Morphogenetic Protein-2-Induced Osteoblastogenesis and Mineralization via Inhibition of Phosphatidylinositol 3-kinases/Akt Pathway

Phloretin has pleiotropic effects, including glucose transporter (GLUT) inhibition. We previously showed that phloretin promoted adipogenesis of bone marrow stromal cell (BMSC) line ST2 independently of GLUT1 inhibition. This study investigated the effect of phloretin on osteoblastogenesis of ST2 ce...

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Bibliographic Details
Main Authors: Ayumu Takeno, Ippei Kanazawa, Ken-ichiro Tanaka, Masakazu Notsu, Toshitsugu Sugimoto
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
phloretin
bone marrow stromal cell
ST2 cell
osteoblast
MC3T3-E1 cell
glucose uptake
osteoblastogenesis
adipogenesis
PI3K/Akt pathway
Online Access:https://www.mdpi.com/1422-0067/20/10/2481

Internet

https://www.mdpi.com/1422-0067/20/10/2481

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