MUC1 Vaccines, Comprised of Glycosylated or Non-Glycosylated Peptides or Tumor-Derived MUC1, Can Circumvent Immunoediting to Control Tumor Growth in MUC1 Transgenic Mice.

MUC1 Vaccines, Comprised of Glycosylated or Non-Glycosylated Peptides or Tumor-Derived MUC1, Can Circumvent Immunoediting to Control Tumor Growth in MUC1 Transgenic Mice.

It remains challenging to produce decisive vaccines against MUC1, a tumor-associated antigen widely expressed by pancreas, breast and other tumors. Employing clinically relevant mouse models, we ruled out such causes as irreversible T-cell tolerance, inadequate avidity, and failure of T-cells to rec...

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Bibliographic Details
Main Authors: Vani Lakshminarayanan, Nitin T Supekar, Jie Wei, Dustin B McCurry, Amylou C Dueck, Heidi E Kosiorek, Priyanka P Trivedi, Judy M Bradley, Cathy S Madsen, Latha B Pathangey, Dominique B Hoelzinger, Margreet A Wolfert, Geert-Jan Boons, Peter A Cohen, Sandra J Gendler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4720451?pdf=render

Internet

http://europepmc.org/articles/PMC4720451?pdf=render

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