Cisplatin preferentially binds to DNA in dorsal root ganglion neurons in vitro and in vivo: a potential mechanism for neurotoxicity

Cisplatin preferentially binds to DNA in dorsal root ganglion neurons in vitro and in vivo: a potential mechanism for neurotoxicity

Cisplatin causes apoptosis of dorsal root ganglia (DRG) neurons. The amount of platinum binding to DNA correlates with cisplatin toxicity in cancer cells11 Genomic DNA platinum content of cultured embryonic DRG neurons and PC12 cells was assayed using inductively coupled plasma mass spectrometry (IC...

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Bibliographic Details
Main Authors: Elizabeth S. McDonald, Kelli R. Randon, Andrew Knight, Anthony J. Windebank
Format: Article
Language:English
Published: Elsevier 2005-03-01
Series:Neurobiology of Disease
Subjects:
Cisplatin
Dorsal root ganglia
Neuron
Sensory neurotoxicity
Apoptosis
Platinum–DNA
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104002256

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http://www.sciencedirect.com/science/article/pii/S0969996104002256

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