Anti-Inflammatory Pyranochalcone Derivative Attenuates LPS-Induced Acute Kidney Injury via Inhibiting TLR4/NF-κB Pathway

Anti-Inflammatory Pyranochalcone Derivative Attenuates LPS-Induced Acute Kidney Injury via Inhibiting TLR4/NF-κB Pathway

Treatment of septic acute kidney injury (AKI) has still been beyond satisfaction, although anti-inflammatory therapy is beneficial for sepsis-induced AKI. Compound 5b was derived from natural pyranochalcones and exhibited potent anti-inflammatory activity in adjuvant-induced arthritis. In this study...

Full description

Bibliographic Details
Main Authors: Min Shi, Xiaoxi Zeng, Fan Guo, Rongshuang Huang, Yanhuan Feng, Liang Ma, Li Zhou, Ping Fu
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Molecules
Subjects:
AKI
pyranochalcone
derivative
anti-inflammation
TLR4
NF-κB
Online Access:https://www.mdpi.com/1420-3049/22/10/1683

Internet

https://www.mdpi.com/1420-3049/22/10/1683

Similar Items