Involvement of endoplasmic reticulum stress in rotenone-induced leber hereditary optic neuropathy model and the discovery of new therapeutic agents

Involvement of endoplasmic reticulum stress in rotenone-induced leber hereditary optic neuropathy model and the discovery of new therapeutic agents

Leber hereditary optic neuropathy (LHON) is caused by mitochondrial DNA mutations and is the most common inherited mitochondrial disease. It is responsible for central vision loss in young adulthood. However, the precise mechanisms of onset are unknown. This study aimed to elucidate the mechanisms u...

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Bibliographic Details
Main Authors: Yakumo Aoyama, Satoshi Inagaki, Kota Aoshima, Yuki Iwata, Shinsuke Nakamura, Hideaki Hara, Masamitsu Shimazawa
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Journal of Pharmacological Sciences
Subjects:
Leber hereditary optic neuropathy
Retinal ganglion cells
Mitochondria
Endoplasmic reticulum stress
Rotenone
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861321000700

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http://www.sciencedirect.com/science/article/pii/S1347861321000700

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