Nucleus accumbens inflammation mediates anxiodepressive behavior and compulsive sucrose seeking elicited by saturated dietary fat

Objective: The incidence of depression is significantly compounded by obesity. Obesity arising from excessive intake of high-fat food provokes anxiodepressive behavior and elicits molecular adaptations in the nucleus accumbens (NAc), a region well-implicated in the hedonic deficits associated with d...

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Bibliographic Details
Main Authors: Léa Décarie-Spain, Sandeep Sharma, Cécile Hryhorczuk, Victor Issa-Garcia, Philip A. Barker, Nathalie Arbour, Thierry Alquier, Stephanie Fulton
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817309389