Epigenetic loss of heterozygosity of Apc and an inflammation-associated mutational signature detected in Lrig1 +/− -driven murine colonic adenomas

Epigenetic loss of heterozygosity of Apc and an inflammation-associated mutational signature detected in Lrig1 +/− -driven murine colonic adenomas

Abstract Background The loss of a single copy of adenomatous polyposis coli (Apc) in leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1)-expressing colonic progenitor cells induces rapid growth of adenomas in mice with high penetrance and multiplicity. The tumors lack functional APC, and...

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Bibliographic Details
Main Authors: Jessica L. Preston, Nicholas Stiffler
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Cancer
Subjects:
Lrig1
Lgr5
Colorectal cancer
Intestinal stem cells
Adenoma
Mutations
Online Access:https://doi.org/10.1186/s12885-020-6616-y

Internet

https://doi.org/10.1186/s12885-020-6616-y

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