PINK1 contained in huMSC-derived exosomes prevents cardiomyocyte mitochondrial calcium overload in sepsis via recovery of mitochondrial Ca2+ efflux

PINK1 contained in huMSC-derived exosomes prevents cardiomyocyte mitochondrial calcium overload in sepsis via recovery of mitochondrial Ca2+ efflux

Abstract Background Sepsis is a systemic inflammatory response to a local severe infection that may lead to multiple organ failure and death. Previous studies have shown that 40–50% of patients with sepsis have diverse myocardial injuries and 70 to 90% mortality rates compared to 20% mortality in pa...

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Bibliographic Details
Main Authors: Qin Zhou, Min Xie, Jing Zhu, Qin Yi, Bin Tan, Yasha Li, Liang Ye, Xinyuan Zhang, Ying Zhang, Jie Tian, Hao Xu
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Stem Cell Research & Therapy
Subjects:
Sepsis
Cardiac dysfunction
PINK1
Calcium overload
Mitochondrial Ca2+ efflux
Online Access:https://doi.org/10.1186/s13287-021-02325-6

Internet

https://doi.org/10.1186/s13287-021-02325-6

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