Genome-Wide Analysis of Interchromosomal Interaction Probabilities Reveals Chained Translocations and Overrepresentation of Translocation Breakpoints in Genes in a Cutaneous T-Cell Lymphoma Cell Line

Genome-Wide Analysis of Interchromosomal Interaction Probabilities Reveals Chained Translocations and Overrepresentation of Translocation Breakpoints in Genes in a Cutaneous T-Cell Lymphoma Cell Line

In classical models of tumorigenesis, the accumulation of tumor promoting chromosomal aberrations is described as a gradual process. Next-generation sequencing-based methods have recently revealed complex patterns of chromosomal aberrations, which are beyond explanation by these classical models of...

Full description

Bibliographic Details
Main Authors: Anne Steininger, Grit Ebert, Benjamin V. Becker, Chalid Assaf, Markus Möbs, Christian A. Schmidt, Piotr Grabarczyk, Lars R. Jensen, Grzegorz K. Przybylski, Matthias Port, Andreas W. Kuss, Reinhard Ullmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Oncology
Subjects:
chromosome conformation capture
chromoplexy
chromosomal translocations
deep sequencing
cutaneous T-cell lymphoma
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00183/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00183/full

Similar Items