Genetic disease risks can be misestimated across global populations

Genetic disease risks can be misestimated across global populations

Abstract Background Accurate assessment of health disparities requires unbiased knowledge of genetic risks in different populations. Unfortunately, most genome-wide association studies use genotyping arrays and European samples. Here, we integrate whole genome sequence data from global populations,...

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Bibliographic Details
Main Authors: Michelle S. Kim, Kane P. Patel, Andrew K. Teng, Ali J. Berens, Joseph Lachance
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Genome Biology
Subjects:
Ascertainment bias
Genetic risk scores
Genetic epidemiology
Genome-wide association studies
Global health
Health disparities
Online Access:http://link.springer.com/article/10.1186/s13059-018-1561-7

Internet

http://link.springer.com/article/10.1186/s13059-018-1561-7

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