Consensus small interfering RNA targeted to stem-loops II and III of IRES structure of 5′ UTR effectively inhibits virus replication and translation of HCV sub-genotype 4a isolates from Saudi Arabia

Consensus small interfering RNA targeted to stem-loops II and III of IRES structure of 5′ UTR effectively inhibits virus replication and translation of HCV sub-genotype 4a isolates from Saudi Arabia

Being the most conserved region of all hepatitis C virus (HCV) genotypes and sub-genotypes, the 5′ untranslated region (5′ UTR) of HCV genome signifies it’s importance as a potential target for anti-mRNA based treatment strategies like RNA interference. The advent and approval of first small interfe...

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Bibliographic Details
Main Authors: Waleed H. AlMalki, Imran Shahid, Ashraf N. Abdalla, Ayman K. Johargy, Muhammad Ahmed, Sajida Hassan
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Saudi Journal of Biological Sciences
Subjects:
HCV
5′ Untranslated region
Internal ribosome entry sites
Replication
Translation
Small interference RNA
Online Access:http://www.sciencedirect.com/science/article/pii/S1319562X20306033

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http://www.sciencedirect.com/science/article/pii/S1319562X20306033

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