YRDC Mediates the Resistance of Lenvatinib in Hepatocarcinoma Cells via Modulating the Translation of KRAS

Lenvatinib is the latest and promising agent that has demonstrated a significant improvement of progression-free survival in advanced hepatocellular carcinoma (HCC). However, resistance emerges soon after initial treatment, limiting the clinical benefits of lenvatinib. Therefore, understanding the m...

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Bibliographic Details
Main Authors: Jun Guo, Peng Zhu, Zhi Ye, Mengke Wang, Haijun Yang, Shiqiong Huang, Yan Shu, Wei Zhang, Honghao Zhou, Qing Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Pharmacology
Subjects:
HCC
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.744578/full