Neuropeptide Y (NPY) intranasal delivery alleviates Machado–Joseph disease

Abstract Machado–Joseph disease (MJD) is the most common dominantly-inherited ataxia worldwide with no effective treatment to prevent, stop or alleviate its progression. Neuropeptide Y (NPY) is a neuroprotective agent widely expressed in the mammalian brain. Our previous work showed that NPY overexp...

Full description

Bibliographic Details
Main Authors: Joana Duarte-Neves, Cláudia Cavadas, Luís Pereira de Almeida
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-82339-5