Patched regulates lipid homeostasis by controlling cellular cholesterol levels

Patched regulates lipid homeostasis by controlling cellular cholesterol levels

Cellular cholesterol levels are tightly regulated. Here, the authors show that the hedgehog signalling receptor PTCH is a cholesterol transporter. Reduction in PTCH activity leads to cellular cholesterol accumulation, changes in nuclear hormone receptor activity and fatty acid metabolism.

Bibliographic Details
Main Authors: Carla E. Cadena del Castillo, J. Thomas Hannich, Andres Kaech, Hirohisa Chiyoda, Jonathan Brewer, Masamitsu Fukuyama, Nils J. Færgeman, Howard Riezman, Anne Spang
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24995-9

Internet

https://doi.org/10.1038/s41467-021-24995-9

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