ABCB1 protects bat cells from DNA damage induced by genotoxic compounds

Bats possess an extended lifespan compared to most mammals of their size, and have a low cancer incidence. Here the authors show that several bat species exhibit resistance to genotoxic agents that is in part attributable to high expression of the ABCB1 transporter.

Bibliographic Details
Main Authors: Javier Koh, Yoko Itahana, Ian H. Mendenhall, Dolyce Low, Eunice Xin Yi Soh, Alvin Kunyao Guo, Yok Teng Chionh, Lin-Fa Wang, Koji Itahana
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10495-4