Elevated α-defensin levels in plasma and bronchoalveolar lavage fluid from patients with myositis-associated interstitial lung disease

Elevated α-defensin levels in plasma and bronchoalveolar lavage fluid from patients with myositis-associated interstitial lung disease

Abstract Background Interstitial lung disease (ILD) is a prognostic indicator of poor outcome in myositis. Although the pathogenesis of myositis-associated ILD is not well understood, neutrophils are thought to play a pivotal role. Neutrophils store azurophil granules that contain defensins, which a...

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Bibliographic Details
Main Authors: Noriho Sakamoto, Hiroshi Ishimoto, Tomoyuki Kakugawa, Minoru Satoh, Tomoko Hasegawa, Shin Tanaka, Atsuko Hara, Shota Nakashima, Hirokazu Yura, Takuto Miyamura, Hanako Koyama, Towako Morita, Seiko Nakamichi, Yasushi Obase, Yuji Ishimatsu, Hiroshi Mukae
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Pulmonary Medicine
Subjects:
Bronchoalveolar lavage fluid
Human neutrophil peptide
Idiopathic inflammatory myopathies
Interstitial lung disease
Online Access:http://link.springer.com/article/10.1186/s12890-018-0609-5

Internet

http://link.springer.com/article/10.1186/s12890-018-0609-5

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