Inhibiting DPP4 in a mouse model of HHT1 results in a shift towards regenerative macrophages and reduces fibrosis after myocardial infarction.

<h4>Aims</h4>Hereditary Hemorrhagic Telangiectasia type-1 (HHT1) is a genetic vascular disorder caused by haploinsufficiency of the TGFβ co-receptor endoglin. Dysfunctional homing of HHT1 mononuclear cells (MNCs) towards the infarcted myocardium hampers cardiac recovery. HHT1-MNCs have e...

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Bibliographic Details
Main Authors: Calinda K E Dingenouts, Wineke Bakker, Kirsten Lodder, Karien C Wiesmeijer, Asja T Moerkamp, Janita A Maring, Helen M Arthur, Anke M Smits, Marie-José Goumans
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0189805