Simultaneous Determination of Aesculin, Aesculetin, Fraxetin, Fraxin and Polydatin in Beagle Dog Plasma by UPLC-ESI-MS/MS and Its Application in a Pharmacokinetic Study after Oral Administration Extracts of Ledum palustre L.

Simultaneous Determination of Aesculin, Aesculetin, Fraxetin, Fraxin and Polydatin in Beagle Dog Plasma by UPLC-ESI-MS/MS and Its Application in a Pharmacokinetic Study after Oral Administration Extracts of Ledum palustre L.

A rapid, simple and sensitive ultra-performance liquid chromatography-electrospray-ionization-tandem mass spectrometry (UPLC-ESI-MS/MS) method was developed and validated for the simultaneous determination of aesculin, aesculetin, fraxetin, fraxin and polydatin in beagle dog plasma for the first tim...

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Bibliographic Details
Main Authors: Zhibin Wang, Wenbo Zhu, Hua Liu, Gaosong Wu, Mengmeng Song, Bingyou Yang, Deqiang Yang, Qiuhong Wang, Haixue Kuang
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Molecules
Subjects:
Ledum palustre L.
UPLC-ESI-MS/MS
pharmacokinetics
Online Access:http://www.mdpi.com/1420-3049/23/9/2285

Internet

http://www.mdpi.com/1420-3049/23/9/2285

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