Photoredox-Catalyzed Enantioselective α-Deuteration of Azaarenes with D2O

Summary: The site-specific incorporation of deuterium (D) into small molecules is frequently used to access isotopically labeled compounds with broad utility in many research areas, such as drug development, mechanistic studies, and NMR analyses. Nevertheless, the deuteration of a stereocenter in an...

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Bibliographic Details
Main Authors: Tianju Shao, Yajuan Li, Nana Ma, Chunyang Li, Guobi Chai, Xiaowei Zhao, Baokun Qiao, Zhiyong Jiang
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219301890