Ubiquitin–proteasome system and the role of its inhibitors in cancer therapy

Despite all the other cells that have the potential to prevent cancer development and metastasis through tumour suppressor proteins, cancer cells can upregulate the ubiquitin–proteasome system (UPS) by which they can degrade tumour suppressor proteins and avoid apoptosis. This system plays an extens...

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Bibliographic Details
Main Authors: Fatemeh Aliabadi, Beheshteh Sohrabi, Ebrahim Mostafavi, Hamidreza Pazoki-Toroudi, Thomas J. Webster
Format: Article
Language:English
Published: The Royal Society 2021-04-01
Series:Open Biology
Subjects:
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.200390