CD81 Receptor Regions outside the Large Extracellular Loop Determine Hepatitis C Virus Entry into Hepatoma Cells

CD81 Receptor Regions outside the Large Extracellular Loop Determine Hepatitis C Virus Entry into Hepatoma Cells

Hepatitis C virus (HCV) enters human hepatocytes using four essential entry factors, one of which is human CD81 (hCD81). The tetraspanin hCD81 contains a large extracellular loop (LEL), which interacts with the E2 glycoprotein of HCV. The role of the non-LEL regions of hCD81 (intracellular tails, fo...

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Bibliographic Details
Main Authors: Pia Banse, Rebecca Moeller, Janina Bruening, Lisa Lasswitz, Sina Kahl, Abdul G. Khan, Joseph Marcotrigiano, Thomas Pietschmann, Gisa Gerold
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Viruses
Subjects:
hepatitis C virus
HCV
tetraspanin
CD81
receptor
chimeras
susceptibility-determining domains
transmembrane domain four
cholesterol-binding residue
Online Access:http://www.mdpi.com/1999-4915/10/4/207

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http://www.mdpi.com/1999-4915/10/4/207

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