Tissue-specific transcriptional regulation of the cholesterol biosynthetic pathway leads to accumulation of testis meiosis-activating sterol (T-MAS)1

Tissue-specific transcriptional regulation of the cholesterol biosynthetic pathway leads to accumulation of testis meiosis-activating sterol (T-MAS)1

Lanosterol 14α-demethylase (CYP51) produces follicular fluid meiosis-activating sterol (FF-MAS), which is converted further to testis meiosis-activating sterol (T-MAS). MAS are intermediates in the cholesterol biosynthetic pathway, with the ability to trigger resumption of oocyte meiosis in vitro. I...

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Bibliographic Details
Main Authors: K. Fon Tacer, T.B. Haugen, M. Baltsen, N. Debeljak, D. Rozman
Format: Article
Language:English
Published: Elsevier 2002-01-01
Series:Journal of Lipid Research
Subjects:
cholesterol biosynthesis
cytochrome P450
lanosterol 14α-demethylase
spermatogenesis and meiosis-activating sterol
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520301905

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http://www.sciencedirect.com/science/article/pii/S0022227520301905

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