Targeting the Integrated Stress Response in Cancer Therapy

Targeting the Integrated Stress Response in Cancer Therapy

The integrated stress response (ISR) is an evolutionarily conserved intra-cellular signaling network which is activated in response to intrinsic and extrinsic stresses. Various stresses are sensed by four specialized kinases, PKR-like ER kinase (PERK), general control non-derepressible 2 (GCN2), dou...

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Bibliographic Details
Main Authors: Xiaobing Tian, Shengliang Zhang, Lanlan Zhou, Attila A. Seyhan, Liz Hernandez Borrero, Yiqun Zhang, Wafik S. El-Deiry
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
integrated stress responses
ATF4
CHOP
apoptosis
cancer treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.747837/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.747837/full

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