CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State

CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State

Poly(A) tail length and mRNA deadenylation play important roles in gene regulation. However, how they regulate embryonic development and pluripotent cell fate is not fully understood. Here we present evidence that CNOT3-dependent mRNA deadenylation governs the pluripotent state. We show that CNOT3,...

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Bibliographic Details
Main Authors: Xiaofeng Zheng, Pengyi Yang, Brad Lackford, Brian D. Bennett, Li Wang, Hui Li, Yu Wang, Yiliang Miao, Julie F. Foley, David C. Fargo, Ying Jin, Carmen J. Williams, Raja Jothi, Guang Hu
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Stem Cell Reports
Subjects:
pluripotent state
pre-implantation development
embryonic stem cell
mRNA deadenylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116302132

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http://www.sciencedirect.com/science/article/pii/S2213671116302132

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