Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability

Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability

The activity-regulated cytoskeleton-associated protein (Arc) has been implicated in synaptic plasticity and memory consolidation. Here the authors show that Arc acetylation regulates its stability and identify small molecules that modulate Arc expression.

Bibliographic Details
Main Authors: Jasmin Lalonde, Surya A. Reis, Sudhir Sivakumaran, Carl S. Holland, Hendrik Wesseling, John F. Sauld, Begum Alural, Wen-Ning Zhao, Judith A. Steen, Stephen J. Haggarty
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01750-7

Internet

https://doi.org/10.1038/s41467-017-01750-7

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