Fat-Produced Adipsin Regulates Inflammatory Arthritis

Summary: We explored the relationship of obesity and inflammatory arthritis (IA) by selectively expressing diphtheria toxin in adipose tissue yielding “fat-free” (FF) mice completely lacking white and brown fat. FF mice exhibit systemic neutrophilia and elevated serum acute phase proteins suggesting...

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Bibliographic Details
Main Authors: Yongjia Li, Wei Zou, Jonathan R. Brestoff, Nidhi Rohatgi, Xiaobo Wu, John P. Atkinson, Charles A. Harris, Steven L. Teitelbaum
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719306527