Loss-of-Function Mutations of <i>BCOR</i> Are an Independent Marker of Adverse Outcomes in Intensively Treated Patients with Acute Myeloid Leukemia

Loss-of-Function Mutations of <i>BCOR</i> Are an Independent Marker of Adverse Outcomes in Intensively Treated Patients with Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is characterized by recurrent genetic events. The <i>BCL6 </i>corepressor<i> (BCOR) </i>and its homolog, the <i>BCL6 corepressor-like 1 (BCORL1)</i>, have been reported to be rare but recurrent mutations in AML. Previously, smaller stu...

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Main Authors:	Jan-Niklas Eckardt, Sebastian Stasik, Michael Kramer, Christoph Röllig, Alwin Krämer, Sebastian Scholl, Andreas Hochhaus, Martina Crysandt, Tim H. Brümmendorf, Ralph Naumann, Björn Steffen, Volker Kunzmann, Hermann Einsele, Markus Schaich, Andreas Burchert, Andreas Neubauer, Kerstin Schäfer-Eckart, Christoph Schliemann, Stefan W. Krause, Regina Herbst, Mathias Hänel, Norbert Frickhofen, Richard Noppeney, Ulrich Kaiser, Claudia D. Baldus, Martin Kaufmann, Zdenek Rácil, Uwe Platzbecker, Wolfgang E. Berdel, Jiří Mayer, Hubert Serve, Carsten Müller-Tidow, Gerhard Ehninger, Friedrich Stölzel, Frank Kroschinsky, Johannes Schetelig, Martin Bornhäuser, Christian Thiede, Jan Moritz Middeke
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Cancers
Subjects:	acute myeloid leukemia <i>BCOR</i> <i>BCORL1</i> loss-of-function risk stratification survival
Online Access:	https://www.mdpi.com/2072-6694/13/9/2095

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https://www.mdpi.com/2072-6694/13/9/2095