Increased excitability in tat-transgenic mice: Role of tat in HIV-related neurological disorders

Increased excitability in tat-transgenic mice: Role of tat in HIV-related neurological disorders

HIV-1 associated neurocognitive disorders (HAND) are a major complication of HIV-1 infection. The mechanism(s) underlying HAND are not completely understood but, based on in vitro studies, the HIV-1 Tat protein may play an important role. In this study, the effect of prolonged exposure to endogenous...

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Bibliographic Details
Main Authors: Silvia Zucchini, Anna Pittaluga, Egidio Brocca-Cofano, Maria Summa, Marina Fabris, Rita De Michele, Angela Bonaccorsi, Graziella Busatto, Giuseppe Barbanti-Brodano, Giuseppe Altavilla, Gianluca Verlengia, Pierangelo Cifelli, Alfredo Corallini, Antonella Caputo, Michele Simonato
Format: Article
Language:English
Published: Elsevier 2013-07-01
Series:Neurobiology of Disease
Subjects:
HIV-1-tat-transgenic mice
HIV-1 associated neurocognitive disorders
Seizures
Kainate
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113000661

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http://www.sciencedirect.com/science/article/pii/S0969996113000661

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