Heat-Inactivation of Human Serum Destroys C1 Inhibitor, Pro-motes Immune Complex Formation, and Improves Human T Cell Function

Heat-Inactivation of Human Serum Destroys C1 Inhibitor, Pro-motes Immune Complex Formation, and Improves Human T Cell Function

<b> </b>Heat-inactivation of sera is used to reduce possible disturbing effects of complement factors in cell-culture experiments, but it is controversially discussed whether this procedure is appropriate or could be neglected. Here, we report a strong impact of heat-inactivation of huma...

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Bibliographic Details
Main Authors: Matthias A. Fante, Sonja-Maria Decking, Christina Bruss, Stephan Schreml, Peter J. Siska, Marina Kreutz, Kathrin Renner
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
T cell activation
complement
serum heat-inactivation
C1 inhibitor
immune complexes
cytokines
Online Access:https://www.mdpi.com/1422-0067/22/5/2646

Internet

https://www.mdpi.com/1422-0067/22/5/2646

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