Using genetic buffering relationships identified in fission yeast to reveal susceptibilities in cells lacking hamartin or tuberin function

Using genetic buffering relationships identified in fission yeast to reveal susceptibilities in cells lacking hamartin or tuberin function

Tuberous sclerosis complex is an autosomal dominant disorder characterized by benign tumors arising from the abnormal activation of mTOR signaling in cells lacking TSC1 (hamartin) or TSC2 (tuberin) activity. To expand the genetic framework surrounding this group of growth regulators, we utilized the...

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Bibliographic Details
Main Authors: Ashyad Rayhan, Adam Faller, Ryan Chevalier, Alannah Mattice, Jim Karagiannis
Format: Article
Language:English
Published: The Company of Biologists 2018-01-01
Series:Biology Open
Subjects:
Tuberous sclerosis complex
Schizosaccharomyces pombe
mTOR
Genetic buffering
Online Access:http://bio.biologists.org/content/7/1/bio031302

Internet

http://bio.biologists.org/content/7/1/bio031302

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