In Search for Multi-Target Ligands as Potential Agents for Diabetes Mellitus and Its Complications—A Structure-Activity Relationship Study on Inhibitors of Aldose Reductase and Protein Tyrosine Phosphatase 1B

In Search for Multi-Target Ligands as Potential Agents for Diabetes Mellitus and Its Complications—A Structure-Activity Relationship Study on Inhibitors of Aldose Reductase and Protein Tyrosine Phosphatase 1B

Diabetes mellitus (DM) is a complex disease which currently affects more than 460 million people and is one of the leading cause of death worldwide. Its development implies numerous metabolic dysfunctions and the onset of hyperglycaemia-induced chronic complications. Multiple ligands can be rational...

Full description

Bibliographic Details
Main Authors: Rosaria Ottanà, Paolo Paoli, Mario Cappiello, Trung Ngoc Nguyen, Ilenia Adornato, Antonella Del Corso, Massimo Genovese, Ilaria Nesi, Roberta Moschini, Alexandra Naß, Gerhard Wolber, Rosanna Maccari
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
multi-target ligands
diabetes mellitus
aldose reductase
protein tyrosine phosphatase 1B
4-thiazolidinones
molecular docking
Online Access:https://www.mdpi.com/1420-3049/26/2/330

Internet

https://www.mdpi.com/1420-3049/26/2/330

Similar Items