Increased dendritic complexity and axonal length in cultured mouse cortical neurons overexpressing methyl-CpG-binding protein MeCP2

Increased dendritic complexity and axonal length in cultured mouse cortical neurons overexpressing methyl-CpG-binding protein MeCP2

Rett syndrome is caused by loss-of-function mutations in the gene encoding the methyl DNA-binding factor MeCP2. As brain mass and neuronal complexity tend to be diminished in Rett patients, we tested whether MeCP2 directly influences the morphological complexity of developing neurons. Our results sh...

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Bibliographic Details
Main Authors: Denis G.M. Jugloff, Benjamin P. Jung, Diana Purushotham, Richard Logan, James H. Eubanks
Format: Article
Language:English
Published: Elsevier 2005-06-01
Series:Neurobiology of Disease
Subjects:
Rett syndrome
Methyl DNA-binding factor
Neuronal culture
Transient overexpression
Axon
Dendrite
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104002748

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http://www.sciencedirect.com/science/article/pii/S0969996104002748

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