Restoring the quantity and quality of elderly human mesenchymal stem cells for autologous cell-based therapies

Restoring the quantity and quality of elderly human mesenchymal stem cells for autologous cell-based therapies

Abstract Background Degenerative diseases are a major public health concern for the aging population and mesenchymal stem cells (MSCs) have great potential for treating many of these diseases. However, the quantity and quality of MSCs declines with aging, limiting the potential efficacy of autologou...

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Bibliographic Details
Main Authors: Travis J. Block, Milos Marinkovic, Olivia N. Tran, Aaron O. Gonzalez, Amanda Marshall, David D. Dean, Xiao-Dong Chen
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Stem Cell Research & Therapy
Subjects:
Aging
Stem cell markers
Cellular senescence
Senescence-associated secretory phenotype
Extracellular matrix
Stem cell niche
Online Access:http://link.springer.com/article/10.1186/s13287-017-0688-x

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http://link.springer.com/article/10.1186/s13287-017-0688-x

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