Heritable stochastic switching revealed by single-cell genealogy.

The partitioning and subsequent inheritance of cellular factors like proteins and RNAs is a ubiquitous feature of cell division. However, direct quantitative measures of how such nongenetic inheritance affects subsequent changes in gene expression have been lacking. We tracked families of the yeast...

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Bibliographic Details
Main Authors: Benjamin B Kaufmann, Qiong Yang, Jerome T Mettetal, Alexander van Oudenaarden
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-09-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC1964776?pdf=render