Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms

Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms

Abstract Yes-associated protein (YAP) and its paralog WW domain containing transcription regulator 1 (TAZ) are important regulators of multiple cellular functions such as proliferation, differentiation, and survival. On the tissue level, YAP/TAZ are essential for embryonic development, organ size co...

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Bibliographic Details
Main Authors: Oleg Dobrokhotov, Mikhail Samsonov, Masahiro Sokabe, Hiroaki Hirata
Format: Article
Language:English
Published: Wiley 2018-08-01
Series:Clinical and Translational Medicine
Subjects:
YAP
TAZ
Hippo pathway
Mechanotransduction
Contact inhibition of proliferation
Actomyosin
Online Access:http://link.springer.com/article/10.1186/s40169-018-0202-9

Internet

http://link.springer.com/article/10.1186/s40169-018-0202-9

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