UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expression of PDK1 through PI3K/AKT signaling

UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expression of PDK1 through PI3K/AKT signaling

Abstract Background UFM1 has been found to be involved in the regulation of tumor development. This study aims to clarify the role and potential molecular mechanisms of UFM1 in the invasion and metastasis of gastric cancer. Methods Expression of UFM1 in gastric tumor and paired adjacent noncancerous...

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Bibliographic Details
Main Authors: Jian-Xian Lin, Xin-Sheng Xie, Xiong-Feng Weng, Sheng-Liang Qiu, Changhwan Yoon, Ning-Zi Lian, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ying-Hong Yang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
UFM1
PDK1
Gastric cancer
EMT
Online Access:http://link.springer.com/article/10.1186/s13046-019-1416-4

Internet

http://link.springer.com/article/10.1186/s13046-019-1416-4

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