Human Retrotransposons and the Global Shutdown of Homeostatic Innate Immunity by Oncolytic Parvovirus H-1PV in Pancreatic Cancer

Human Retrotransposons and the Global Shutdown of Homeostatic Innate Immunity by Oncolytic Parvovirus H-1PV in Pancreatic Cancer

Although the oncolytic parvovirus H-1PV has entered clinical trials, predicting therapeutic success remains challenging. We investigated whether the antiviral state in tumor cells determines the parvoviral oncolytic efficacy. The interferon/interferon-stimulated genes (IFN/ISG)-circuit and its major...

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Bibliographic Details
Main Authors: Matthias Neulinger-Muñoz, Dominik Schaack, Svetlana P. Grekova, Andrea S. Bauer, Thomas Giese, Gabriel A. Salg, Elisa Espinet, Barbara Leuchs, Anette Heller, Jürg P. F. Nüesch, Miriam Schenk, Michael Volkmar, Nathalia A. Giese
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Viruses
Subjects:
oncolytic parvovirus H-1PV
innate immunity
interferon
ISG
HERV
pancreatic cancer
Online Access:https://www.mdpi.com/1999-4915/13/6/1019

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https://www.mdpi.com/1999-4915/13/6/1019

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