Intravascular Endothelin-1 does not trigger or increase susceptibility to Spreading Depolarizations

Intravascular Endothelin-1 does not trigger or increase susceptibility to Spreading Depolarizations

Abstract Objectives Spreading depolarizations (SD) likely manifest as aura in migraineurs. Triggers are unknown although vascular events have been implicated. Direct carotid puncture has been reported to trigger migraine with aura. The potent vasoconstrictor endothelin-1 (ET-1), which can be release...

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Bibliographic Details
Main Authors: Kazutaka Sugimoto, Andreia Morais, Homa Sadeghian, Tao Qin, David Y. Chung, Messoud Ashina, Anders Hougaard, Cenk Ayata
Format: Article
Language:English
Published: BMC 2020-10-01
Series:The Journal of Headache and Pain
Subjects:
Endothelin-1
Spreading depolarization
Migraine aura
Online Access:http://link.springer.com/article/10.1186/s10194-020-01194-3

Internet

http://link.springer.com/article/10.1186/s10194-020-01194-3

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