Brain profiling in murine colitis and human epilepsy reveals neutrophils and TNFα as mediators of neuronal hyperexcitability

Brain profiling in murine colitis and human epilepsy reveals neutrophils and TNFα as mediators of neuronal hyperexcitability

Abstract Background Patients with chronic inflammatory disorders such as inflammatory bowel disease frequently experience neurological complications including epilepsy, depression, attention deficit disorders, migraines, and dementia. However, the mechanistic basis for these associations is unknown....

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Bibliographic Details
Main Authors: Sarah E. Barnes, Kristy A. Zera, Geoffrey T. Ivison, Marion S. Buckwalter, Edgar G. Engleman
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Neuroinflammation
Subjects:
Colitis
Inflammatory bowel disease
Epilepsy
Neuronal hyperexcitability
Neutrophils
TNFα
Online Access:https://doi.org/10.1186/s12974-021-02262-4

Internet

https://doi.org/10.1186/s12974-021-02262-4

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