Purinergic Signaling in the Pathophysiology and Treatment of Huntington’s Disease

Purinergic Signaling in the Pathophysiology and Treatment of Huntington’s Disease

Huntington’s disease (HD) is a devastating, progressive, and fatal neurodegenerative disorder inherited in an autosomal dominant manner. This condition is characterized by motor dysfunction (chorea in the early stage, followed by bradykinesia, dystonia, and motor incoordination in the late stage), p...

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Bibliographic Details
Main Authors: Melissa Talita Wiprich, Carla Denise Bonan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Neuroscience
Subjects:
Huntington’s disease
motor dysfunction
A2A receptors
adenosine
ATP
nucleotide metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.657338/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.657338/full

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