IGF-1 influences Everolimus activity in medullary thyroid carcinoma

IGF-1 influences Everolimus activity in medullary thyroid carcinoma

Context: Medullary thyroid carcinoma (MTC) is a rare tumor originating from thyroid parafollicular C cells. It has been previously demonstrated that IGF-I protects MTC from the effects of anti-proliferative drugs. Everolimus, an mTOR inhibitor, has shown potent anti-proliferative effects in a human...

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Bibliographic Details
Main Authors: Erica eGentilin, Carmelina eDi Pasquale, Martina eRossi, Federico eTagliati, Teresa eGagliano, Roberta eRossi, Mariarosa ePelizzo, Isabella eMerante Boschin, Ettore C degli Uberti, Maria Chiara eZatelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Endocrinology
Subjects:
Calcitonin
IGF-I
mTOR
Everolimus
medullary thyroid carcinoma
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00063/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00063/full

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