A Carbamoyl Phosphate Synthetase II (CPSII) Deletion Mutant of Toxoplasma gondii Induces Partial Protective Immunity in Mice

A Carbamoyl Phosphate Synthetase II (CPSII) Deletion Mutant of Toxoplasma gondii Induces Partial Protective Immunity in Mice

Toxoplasma gondii is an obligate intracellular protozoan parasite. T. gondii primarily infection in pregnant women may result in fetal abortion, and infection in immunosuppressed population may result in toxoplasmosis. Carbamoyl phosphate synthetase II (CPSII) is a key enzyme in the de novo pyrimidi...

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Bibliographic Details
Main Authors: Xunhui Zhuo, Kaige Du, Haojie Ding, Di Lou, Bin Zheng, Shaohong Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Microbiology
Subjects:
Toxoplasma gondii
carbamoyl phosphate synthetase II
vaccine
immunization
CRISPR/Cas9
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.616688/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2020.616688/full

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