Synthesis, in silico ADME, molecular docking and in vitro cytotoxicity evaluation of stilbene linked 1,2,3-triazoles

Synthesis, in silico ADME, molecular docking and in vitro cytotoxicity evaluation of stilbene linked 1,2,3-triazoles

Series of (E)-1-benzyl-4-((4-styrylphenoxy)methyl)-1H-1,2,3-triazoles 7a-x were obtained by Wittig reaction between 4-((1-benzyl-1H-1,2,3-triazol-4-yl)methoxy)benzaldehydes 5a-d and benzyl triphenylphosphonium halides 6a-f in benzene. The structures of the synthesized compounds were confirmed by FTI...

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Bibliographic Details
Main Authors: Arnika Das, Sujeet Kumar, Leentje Persoons, Dirk Daelemans, Dominique Schols, Hakan Alici, Hakan Tahtaci, Subhas S. Karki
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Heliyon
Subjects:
Wittig reaction
1,2,3-Triazole
Cytotoxicity
ADME
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020327353

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http://www.sciencedirect.com/science/article/pii/S2405844020327353

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