Characterization of α1-antitrypsin as a heme oxygenase-1 suppressor in Alzheimer plasma

Characterization of α1-antitrypsin as a heme oxygenase-1 suppressor in Alzheimer plasma

Heme oxygenase-1 (HO-1) mRNA and protein levels are diminished in Alzheimer disease (AD) blood, cerebrospinal fluid (CSF) and choroid plexus. Herein, the presence of a heme oxygenase-1 suppressor (HOS) factor was ascertained by astroglial bioassay, biochemical techniques and immunofluorescence confo...

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Bibliographic Details
Main Authors: Olivier C. Maes, Steven Kravitz, Yogesh Mawal, Haixiang Su, Adrienne Liberman, Khalil Mehindate, Dan Berlin, Demetrios J. Sahlas, Howard M. Chertkow, Howard Bergman, Calvin Melmed, Hyman M. Schipper
Format: Article
Language:English
Published: Elsevier 2006-10-01
Series:Neurobiology of Disease
Subjects:
Aging
α1-Antitrypsin
Alzheimer
Astrocyte
Heme oxygenase-1
Iron
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106001380

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http://www.sciencedirect.com/science/article/pii/S0969996106001380

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