IL-27-Induced Type 1 Regulatory T-Cells Produce Oxysterols that Constrain IL-10 Production

IL-27-Induced Type 1 Regulatory T-Cells Produce Oxysterols that Constrain IL-10 Production

The behaviors of lymphocytes, including CD4+ T helper cells, are controlled on many levels by internal metabolic properties. Lipid metabolites have recently been ascribed a novel function as immune response modulators and perturbation of steroids pathways modulates inflammation and potentially promo...

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Bibliographic Details
Main Authors: Solenne Vigne, Fanny Chalmin, Donovan Duc, Aurélie S. Clottu, Lionel Apetoh, Jean-Marc A. Lobaccaro, Isabelle Christen, Juan Zhang, Caroline Pot
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
immunometabolism
CD4+ T cells
type 1 regulatory T cells
autoimmunity
oxysterols
cholesterol 25-hydroxylase
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01184/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01184/full

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