In Vitro Assessment of the Effect of Antiepileptic Drugs on Expression and Function of ABC Transporters and Their Interactions with ABCC2

In Vitro Assessment of the Effect of Antiepileptic Drugs on Expression and Function of ABC Transporters and Their Interactions with ABCC2

ABC transporters have a significant role in drug disposition and response and various studies have implicated their involvement in epilepsy pharmacoresistance. Since genetic studies till now are inconclusive, we thought of investigating the role of xenobiotics as transcriptional modulators of ABC tr...

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Bibliographic Details
Main Authors: Gurpreet Kaur Grewal, Samiksha Kukal, Neha Kanojia, Krateeka Madan, Luciano Saso, Ritushree Kukreti
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Molecules
Subjects:
antiepileptic drugs
ABC transporters
ABCC2
efflux activity
ATPase assay
Online Access:https://www.mdpi.com/1420-3049/22/10/1484

Internet

https://www.mdpi.com/1420-3049/22/10/1484

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