TP53-induced glycolysis and apoptosis regulator alleviates hypoxia/ischemia-induced microglial pyroptosis and ischemic brain damage

TP53-induced glycolysis and apoptosis regulator alleviates hypoxia/ischemia-induced microglial pyroptosis and ischemic brain damage

Our previous studies have demonstrated that TP53-induced glycolysis and apoptosis regulator (TIGAR) can protect neurons after cerebral ischemia/reperfusion. However, the role of TIGAR in neonatal hypoxic-ischemic brain damage (HIBD) remains unknown. In the present study, 7-day-old Sprague-Dawley rat...

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Bibliographic Details
Main Authors: Lan-Lan Tan, Xiao-Lu Jiang, Li-Xiao Xu, Gen Li, Chen-Xi Feng, Xin Ding, Bin Sun, Zheng-Hong Qin, Zu-Bin Zhang, Xing Feng, Mei Li
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Neural Regeneration Research
Subjects:
hypoxic-ischemic brain damage; in vitro; in vivo; microglia; nadph; pyroptosis; ros; tigar
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=6;spage=1037;epage=1043;aulast=Tan

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=6;spage=1037;epage=1043;aulast=Tan

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