Dual effects of brain sparing opioid in newborn rats: Analgesia and hyperalgesia
Effective pain management in neonates without the unwanted central nervous system (CNS) side effects remains an unmet need. To circumvent these central effects we tested the peripherally acting (brain sparing) opioid agonist loperamide in neonate rats. Our results show that: 1) loperamide (1 mg/kg,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-01-01
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| Series: | Neurobiology of Pain |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452073X17300296 |