Atorvastatin reduces β-Adrenergic dysfunction in rats with diabetic cardiomyopathy.

Atorvastatin reduces β-Adrenergic dysfunction in rats with diabetic cardiomyopathy.

In the diabetic heart the β-adrenergic response is altered partly by down-regulation of the β1-adrenoceptor, reducing its positive inotropic effect and up-regulation of the β3-adrenoceptor, increasing its negative inotropic effect. Statins have clinical benefits on morbidity and mortality in diabeti...

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Bibliographic Details
Main Authors: Aude Carillion, Sarah Feldman, Na Na, Matthieu Biais, Wassila Carpentier, Aurélie Birenbaum, Nicolas Cagnard, Xavier Loyer, Dominique Bonnefont-Rousselot, Stéphane Hatem, Bruno Riou, Julien Amour
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5519044?pdf=render

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http://europepmc.org/articles/PMC5519044?pdf=render

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