EDEM3 Modulates Plasma Triglyceride Level through Its Regulation of LRP1 Expression

EDEM3 Modulates Plasma Triglyceride Level through Its Regulation of LRP1 Expression

Summary: Human genetics studies have uncovered genetic variants that can be used to guide biological research and prioritize molecular targets for therapeutic intervention for complex diseases. We have identified a missense variant (P746S) in EDEM3 associated with lower blood triglyceride (TG) level...

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Bibliographic Details
Main Authors: Yu-Xin Xu, Gina M. Peloso, Taylor H. Nagai, Taiji Mizoguchi, Amy Deik, Kevin Bullock, Honghuang Lin, Kiran Musunuru, Qiong Yang, Ramachandran S. Vasan, Robert E. Gerszten, Clary B. Clish, Daniel Rader, Sekar Kathiresan
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220301577

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http://www.sciencedirect.com/science/article/pii/S2589004220301577

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